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Senior Medical Director, Early Global Development, Oncology R&D

Closing date
3 Aug 2021

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Job Details

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.

We have a bold ambition to provide cures for cancer in every form. We are following the science to understand cancer and all its complexities to discover, develop and deliver life-changing treatments and increase the potential to save the lives of people around the world.

Our Oncology strategy is built with one goal in mind - to push the boundaries of science to change the practice of medicine and transform the lives of patients living with cancer. Our broad pipeline of next-generation medicines, together with our focus on excellence in execution, are aimed at expanding treatment options and improving outcomes for patients with solid tumours and haematological cancers.

We focus on four strategic priorities:

Pioneering research across six scientific platforms: Tumour drivers and resistance; Immuno-oncology; DNA damage response, Antibody drug conjugates, Epigenetics and Cell therapies

Advancing innovative clinical strategies to treat early stages of disease and relapsed or refractory patients

Building expertise and leadership in the most prevalent and highest mortality rate tumour types

Delivering across our global footprint

Oncology Research & Development
Join the team dedicated to Oncology, with an ambition to eliminate cancer as a cause of death. It's our big vision that unites and inspires us.

With multiple indications and high-quality molecules at all stages of our innovative pipeline, we keep pushing forward. Fusing ground breaking science with the latest technology to achieve breakthroughs. Backed by investment, we thrive to deliver 6 new molecular entities by 2025.

A place built on courage, curiosity and collaboration - we make ambitious decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.

One area of significant investment is to build internal infrastructure to be a leader in next generation of products in Oncology. Using historical expertise in biologics engineering, gene editing and immune expertise across solid and

haematological malignancies, AstraZeneca is uniquely positioned to develop the best technologies and is already growing a differentiated pipeline.


Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's important to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you...

Where Science thrives...Cambridge is one of the most exciting bioscience hotspots in the world, playing a central role in our mission to deliver life changing medicines to patients across the globe.

Central Cambridge - Located in walking distance from the Train station, you will have access to an onsite gym, restaurant facilities and experience working within a calm and relaxing agile environment, inspired by the University Botanical gardens.

The site provides access to a stylish, fully air conditioned fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a bright and spacious environment while utilising the most advanced technology.

Position Summary:
We are seeking a well-trained Senior Medical Director who is a clinician with strong leadership skills who is driven by science and the desire to develop novel therapies for cancer patients, and has a proficiency in the drug development process (especially early phase clinical trials), protocol writing & study conduct, data review and reconciliation, the principles of translational medicine, and what it takes to lead teams successfully. This individual will have the opportunity for growth and development while working in a vibrant environment.

You would join AstraZeneca at a time of tremendous growth and acceleration in the oncology portfolio and work within 5 different scientific platforms. This is a fast-paced and dynamic work environment where, with growing levels of responsibility. You will be responsible for:

Providing long-range clinical development planning, planning and managing of clinical research projects and clinical development programs in oncology.
Serve as the Project Medical Monitor while working in a cross functional environment with representatives from other involved line functions as well as Late-Stage Development.
Contribute to and support Department/Clinical initiatives to improve the quality and content of all clinical programs as well as the cross functional/organization processes designed to effectively deliver our R&D portfolio.
Serve as medical monitor with primary responsibility for patient safety and conduct of assigned trials as well as overall data interpretation and safety surveillance;
Establish and approve scientific methods for design and implementation of applicable clinical protocols, data collection systems, and final reports;
Responsible for assisting in design of clinical development plans and overall strategy for compounds, therapeutic classes of compounds or indications in light of developments in the area of clinical and pharmaceutical oncology;
Collaborate with pre-clinical and translational sciences, and senior management in assessing requirements for emerging products; Provide leadership on cross-functional product development team(s) as experience allows;
Participate in identification, selection and conduct of negotiations with clinical research centers and investigators;
Participate in the selection and management activities of CROs; Supervise project team members in planning, conducting and evaluating clinical trials;
Lead all aspects of planning and management of investigator meetings, advisory boards and other scientific committees.
We are seeking a well-trained clinician with strong leadership skills who is driven by science and the desire to develop novel oncology therapies for cancer patients. Additionally, you will have a clear understanding of the drug development process (especially early phase clinical trials), protocol writing & study conduct, data review and reconciliation, the principles of translational medicine, and what it takes to lead teams successfully.

Essential Requirements:

Education & experience:

MD or equivalent required and board certified (or eligible) preferred in Oncology. At least several years of experience in clinical research and/or oncology drug development in pharmaceutical or CRO environment.

PhD in a relevant research area is preferred.

Preferred Requirements:

Experience in molecular oncology and/or translational science
Medical specialty and sub-specialty training and Board Certification
Excellent oral and written skills, strong interpersonal and listening skills
Results driven to achieve creative and sound outcomes
Proven leadership skills and demonstrated ability to interact collaboratively in a cross-functional environment.
Ability to make sound and timely decisions; agile in learning and proactive in your approach
High level of emotional intelligence; able to deal with ambiguity
Able to relate to varied level audiences across the organization; able to set priorities for team and maintain accountability; skilful in negotiating organizational boundaries and hierarchy; able to build effective teams
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