Senior Scientist - Mass Spectrometry

Slough, UK
23 May 2019
27 May 2019
Contract Type
Full Time
At UCB everything we do starts with a simple question: "How will this make a difference to the lives of people living with severe diseases?" We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

Role Overview

The Protein Structure and Biophysics department, within the R&D sector of UCB, comprises 4 sub-groups: Protein Production, Protein Structure, Protein Biophysics and Physical and Analytical Sciences Group (PASG). The Protein Biophysics Group provides support for projects from early stage target validation through to those undergoing pre-clinical evaluation. This involves screening and selection of robust therapeutic antibody molecules using different biophysical methods generated from our different discovery platforms, plus contribution to mechanistic and structural understanding of new protein targets.

As part of the Biophysics Group, you will be a high calibre, laboratory-based candidate, with expertise in mass spectrometry, who can quickly integrate into this highly motivated and focussed team. You will have a key role in the characterisation of protein molecules across a wide range of our NBE and NCE projects significantly contributing to timely progression of these projects into the clinic and beyond.

Primary Responsibilities

Have experience in native /ion mobility mass spectrometry to inform on structural and mechanistic understanding of novel antibody/protein molecule/ligand interactions across a range of different projects.
It would be preferable to have expertise in the handling of membrane proteins-lipid interactions and development of efficient, reliable methods in this exciting field of mass spectrometry.
Demonstrate in depth knowledge of software packages and their application to large molecule (small molecule) data acquisition and processing.

Contribute to the development of novel mass spectrometry technology in the Biophysics team.
Share knowledge and experience across UCB's mass spectrometry community.
Act as an ambassador for UCB by proactively communicating science externally via oral communications at scientific meetings and through publications in peer reviewed scientific journals.

Essential Experience

A PhD (or equivalent) with 2-4 years' experience of 'hands-on' mass spectrometry for structural and mechanistic analysis of antibody/protein/ligand interactions using a range of different equipment, preferably within an industrial or highly regarded academic laboratory in a Biophysics/ Biochemistry environment.
Proven track record of publications related to mass spectrometry applications in peer reviewed, high quality science journals.
Highly motivated individual with excellent attention to detail and critical data analysis skills.
Exceptional organisational skills with proven ability to deliver to tight timelines.
Flexibility in learning new techniques including biophysical / biochemical analysis skills.
Excellent communication and team-working ability.

We can offer you an informal and friendly working environment. You will be exposed to a variety of projects and receive regular coaching and input from the teams you are working with.

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