Research Scientist - Mass Spectrometry/Biophysics

Recruiter
UCB S.A
Location
Slough
Posted
18 Apr 2019
Closes
28 Apr 2019
Sector
Healthcare
Contract Type
Permanent
Hours
Full Time
At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

Role Overview

The Protein Structure and Biophysics department, within the R&D sector of UCB, comprises 4 sub-groups: Protein Production, Protein Structure, Protein Biophysics and Physical and Analytical Sciences Group (PASG). The Protein Biophysics Group provides support for projects from early stage target validation through to those undergoing pre-clinical evaluation. This involves screening and selection of robust therapeutic antibody molecules using different biophysical methods generated from our different discovery platforms, plus contribution to mechanistic and structural understanding of new protein targets.

As part of the Biophysics Group, you will be a high calibre, laboratory-based candidate, with expertise in mass spectrometry, who can quickly integrate into this highly motivated and focussed team. You will have a key role in the characterisation of protein molecules across a wide range of our NBE and NCE projects significantly contributing to timely progression of these projects into the clinic and beyond.

This role will be based in Slough, UK.

Primary Responsibilities


Analyse intact, folded antibody/protein molecules across a number of research projects on a routine basis to inform on product integrity. Antibody knowledge would be an advantage.
Demonstrate in depth knowledge of software packages (for example, MassLynx) and their application to large molecule (small molecule) data acquisition and processing across a broad range of Waters LC/MS systems.
Identify and flag susceptible post-translational modifications (PTMs) to inform and mitigate risk for product stability.
Have experience with native MS to explore PPI and small molecule-protein interactions.
Have expertise in chromatography method development for large molecule (and small molecule) LC/MS analysis.
Demonstrate maintenance and troubleshooting of a broad spectrum of LC/MS systems operating in standalone and open access environments, for example, Waters Acquity LC systems with QDA, Xevo Q-ToF, G2-HDMS
Contribute to the development of novel mass spectrometry technology in the Biophysics team.
Share knowledge and experience across UCB’s mass spectrometry community.
Act as an ambassador for UCB by proactively communicating science externally via oral communications at scientific meetings and through publications in peer reviewed scientific journals.


Essential Requirements


A new PhD or post graduate with 2-4 years’ experience of ‘hands-on’ mass spectrometry characterisation of antibody/protein molecules using a range of different equipment, preferably within an industrial or highly regarded academic laboratory in a Biophysics/ Biochemistry environment.
Proven track record of publications related to mass spectrometry applications in peer reviewed, high quality science journals.
Highly motivated individual with excellent attention to detail and critical data analysis skills.
Exceptional organisational skills with proven ability to deliver to tight timelines.
Flexibility in learning new techniques including biophysical / biochemical analysis skills.
Excellent communication and team-working ability.


We can offer you an informal, friendly and open working environment. You will be exposed to a variety of projects and receive regular coaching and input from the teams you are working with. The opportunity to work across different departments of the organisation to enhance your skill base and become the "go to" person.

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