Research Scientist - Protein Purification

Recruiter
UCB S.A
Location
Slough
Posted
17 Mar 2019
Closes
31 Mar 2019
Sector
Healthcare
Contract Type
Permanent
Hours
Full Time
At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

Role overview

We are looking for a skilled protein biochemist with experience of protein purification, protein titer analysis, protein quality analysis and impurity analysis. The scientist will join a high-performing team responsible for the generation of antibody proteins and will take a lead role in supporting the Cell Line Development Team for the selection of lead therapeutic cell lines. The Antibody Production Sciences Team is responsible for the generation of antibody and protein reagents across Research and support the Cell Line Development Team in the selection of high yielding cell lines producing high quality product, and that are suitable for downstream process optimization.

Primary responsibilities


Purification of novel antibody and non-antibody biologicals from a variety of expression platforms, including (but not limited to) the ambr® 15 bioreactor.
To perform high throughput protein purification and analytical assays, and to understand/interpret data to support the Cell Line Development Team in the selection of lead cell lines.
To aid in the identification, and transfer or development, of new methods to measure other quality attributes that can impact production, quality and yield.
To identify purification and quality risks for downstream manufacturing processes and alert stakeholders with observations/solutions.
Data dissemination via informal/formal presentations.
Maintenance of key purification and analytical equipment.


Essential requirements

Candidates will ideally have completed a relevant BSc/MSc with some experience in industry within a similar role.

We are looking for candidates who can demonstrate working knowledge of most of, and expertise in some of the following skill sets:


Skilled protein biochemist with a sound knowledge of antibody structure and function.
Expert in protein purification, including the use of AKTA purification systems and Unicorn software. Experience in the use of the AKTA Pure system and Unicorn 7.2 is desirable.
Experience performing relevant protein quality and impurities assays (IEF, SDS-PAGE, LabChip, Size Exclusion, UPLC/HPLC, Octet and ELISA etc.).
Experience of LC-MS techniques for intact Mass and glycan analysis is desireable.
Experience in the interpretation of purification and analytical assay data.
Experience in the development/transfer and implementation of new analytical assays.
Strong team-working skills and able to collaborate across multi-disciplinary groups.
Ability to organize work effectively and manage time to work on multiple projects.
Excellent communication skills.
Good writing skills, including report generation.
General knowledge of lab and IT software systems including Office, eLabBooks, as well as searching for literature and patents.

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