Research Associate (Studying Insulin Protection During Pancreatitis)

Recruiter
University of Manchester
Location
Manchester
Salary
£31,076 to £32,600 per annum
Posted
13 Apr 2017
Closes
12 May 2017
Sector
Education
Contract Type
Permanent
Hours
Full Time

A MRC-funded Research Associate position is available for 3 years (start date 01/12/16) to study the protective effects of insulin during pancreatitis. Our previous and preliminary studies have shown that insulin directly protects pancreatic acinar cells during pancreatitis. This is due to a metabolic shift towards glycolysis that preserves ATP to fuel the plasma membrane Ca 2+ pumps and prevent cytotoxic Ca 2+ overload and cellular injury. You will investigate the precise signaling, pathways and metabolic phenotype responsible for these protective effects of insulin in pancreatic acinar cells. The project will use a multidisciplinary approach, including proteomics, metabolomics, fluorescence imaging and in vivo models of pancreatitis. Experience in a range of these techniques would be a distinct advantage. There will be opportunities for a research visit to the laboratory of our collaborators at the University of Michigan to learn and oversee in vivo experiments.

Publication(s)

Samad A, James A, Wong J, Mankad P, Whitehouse J, Patel W, Alves-Simoes M, Sirwardena AK & Bruce JIE. (2014) Insulin protects pancreatic acinar cells from palmitoleic acid-induce cellular injury. J Biol Chem . 289 (34) 23582-95

Mankad P, Siriwardena AK, Elliott AC, Bruce JIE (2012). Insulin protects rat pancreatic acinar cells from oxidant-induced inhibition of the plasma membrane calcium pump. J. Biol Chem. 287, 1823-1836.

The School is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women's careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. The School holds a Bronze Award for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post.
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