Upstream Vector Scientist, Manufacturing

Recruiter
Adaptimmune Limited
Location
Stevenage
Posted
10 Feb 2018
Closes
15 Feb 2018
Sector
Healthcare
Contract Type
Permanent
Hours
Full Time
MS&T for vector is a critical function within Adaptimmune to enable new vector manufacturing processes to be transitioned from Process Development into cGMP manufacture.

Responsibilities include providing cGMP experience, Manufacturing, Commissioning/Validation including the writing and execution of IQ, OQ and PQ documents. An expert knowledge of Fermentation and Primary Recovery in Single Use Bioreactors.

Experienced in the writing, reviewing of different types of documentation including SOP, MBR/PBR, A good knowledge of tech transfer is desirable but not important.

This role will be responsible for the cGMP manufacturing for viral vectors at the Cell and Gene Therapy Catapult's Manufacturing Centre in Stevenage as well as any potential future internal manufacturing operations. Vector MS&T will also need to communicate feedback on experience in cGMP conditions to Process Development.

Required and desirable educational requirements, experience and qualifications

Required:

Either : BSc qualification in relevant area. Deep and extensive industrial experience with bioprocess cGMP manufacturing and biopharmaceutical fields will be required.

- Experience with bioprocessing in Single Use technology would be a significant advantage
- Extensive experience with tech transfer and scale-up of bioprocesses
- Knowledge of and experience operating Single Use bioprocess equipment
- Bioprocess experience with upstream unit operations - Aseptic cell culture
- Bioreactor (stirred tank and rocking motion)
- Filtration (Normal Flow and Tangential Flow)
- Closed systems
-

Or : 'A level' Qualified with some laboratory based experience who is eager to learn new techniques in Vector Manufacture

Desired:

- cGMP experience including authoring of SOPs, Process Descriptions, Batch Records, Qualification documents, Deviation, CAPA and Change Control
- Bioprocess equipment commissioning, qualification and validation

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